纳豆激酶
心肌梗塞
溶栓
血栓
氧化应激
医学
血栓形成
心脏病学
溶栓药
内科学
药理学
化学
生物化学
发酵
作者
Yingchao Shi,Chuan‐Fen Liu,Yuesheng Gui,Yike Guo,Yuanhao Zhang,Jiangpeng Pan,Hao Tang,Chuanyu Gao,Junyue Xing,Yu Han,Wei Jiang
标识
DOI:10.1002/adhm.202402763
摘要
Acute myocardial infarction (MI) induced by thrombus formation is a prevalent cardiovascular disorder, and thrombolytic therapy continues to be a principal treatment modality. Prior research indicates a substantial association among MI, thrombosis, and the activation of oxidative stress pathways. The effectiveness of current thrombolytic drugs is relatively constrained, and the need for innovative and versatile thrombolytic medications remains critical. Nattokinase (NK) is a naturally-occurring enzyme known for its thrombolytic characteristics. Nonetheless, nattokinase's limited stability and susceptibility to inactivation in biological systems have impeded its clinical utility. This study designs a manganese oxide nanozyme (MnOx) loaded with NK (MnOx@NK), which exhibits both antioxidant and thrombolytic function. The administration of MnOx@NK through tail vein injection significantly restores vascular function and further reduces myocardial injury in a mouse model of myocardial infarction, demonstrating a pronounced protective effect against oxidative stress. These findings indicate that nattokinase-loaded nanozymes can be a promising approach for treating acute myocardial infarction, providing a new strategy for clinical application.
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