Preparation and application of collagen-based hemostatic materials: a review

Abstract Traumatic wounds are the prevalent scenarios encountered in battleground and emergency rooms. The rapid and effective hemostasis is imperative for life saving in these scenarios, for which the development of high-efficiency and biocompatible hemostatic materials is essential. Due to its excellent hemostatic property and biocompatibility, collagen has emerged as an ideal component of hemostatic materials. Furthermore, the properties of collagen-based hemostatic materials could be improved by the integration of other biomacromolecules, such as alginate, cellulose derivatives, and chitosan derivatives. Therefore, more and more novel hemostatic materials with exceptional hemostatic properties have been developed. This review aims to overview recent progress of collagen-based hemostatic materials. Firstly, the hemostatic mechanism of collagen was introduced. Secondly, various forms of collagen-based hemostatic materials, such as hydrogels, sponges, and powders, were highlighted. Thirdly, composite hemostatic materials of collagen and other biomacromolecules were overviewed. Finally, the outlook of collagen-based hemostatic materials was discussed. Graphical abstract