Sex- and timing-specific effects of fasting and caloric restriction

Optimizing food quantity and fasting time may improve health and lifespan. We summarize emerging knowledge on sex, age, and circadian timing as important determinants for the efficacy of dietary interventions and highlight results from Duregon et al. pointing to a favorable combination of caloric restriction (CR) and fasting in aged female mice. Optimizing food quantity and fasting time may improve health and lifespan. We summarize emerging knowledge on sex, age, and circadian timing as important determinants for the efficacy of dietary interventions and highlight results from Duregon et al. pointing to a favorable combination of caloric restriction (CR) and fasting in aged female mice. Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female miceDuregon et al.Cell MetabolismJuly 11, 2023In BriefIn this study, Duregon et al. reveal greater benefits of a mild reduction of caloric intake over time-restricted feeding in adult female mice, highlighting the added contribution of reduced energy intake to further improvement of the effects of daily fasting in terms of fitness, in vivo metabolism, and survival. Full-Text PDF