丝素
明胶
亚甲蓝
生物相容性
伤口愈合
材料科学
纳米颗粒
自愈水凝胶
化学工程
化学
生物医学工程
纳米技术
核化学
丝绸
高分子化学
复合材料
光催化
有机化学
外科
医学
工程类
冶金
催化作用
作者
Zhuoyuan Li,Zheng Ao,Zhiyuan Mao,Fupeng Li,Tingshu Su,Lingyan Cao,Wei Wang,Yang Liu,Chen Wang
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2023-06-13
卷期号:9 (5): 773-773
被引量:12
摘要
Photo-crosslinked hydrogel (PH) is an outstanding candidate for three-dimensional (3D) printing as a wound dressing because of its high efficiency in crosslinking and injectability. In this study, methylene blue (MB)-loaded UiO-66(Ce) nanoparticles (NPs) were synthesized to prevent drug self-aggregation and achieve the photodynamic therapy (PDT) effect for efficient antibacterial action. Then, a composite photocrosslinked silk fibroin (SF)/gelatin hydrogel loaded with MB@UiO-66(Ce) NPs (MB@UiO-66(Ce)/PH) was fabricated. The printability and the improvement of the mechanical properties of the hydrogel by the NPs were clarified. The hydrogel exhibited good biocompatibility and promoted the migration and proliferation of fibroblasts. With the PDT effect of MB@UiO-66(Ce) NPs, the hydrogel showed an excellent antibacterial effect, which became more pronounced as the concentration increased. In vivo study showed that the MB@UiO-66(Ce)/PH could fill the defects without gaps and accelerate the repair rate of full-thickness skin defects in mice. The MB@UiO-66(Ce)/PH with antibacterial properties and tissue healing-promoting ability provides a new strategy involving 3D bioprinting for preparing wound dressings.
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