肿瘤微环境
免疫系统
免疫疗法
生物
免疫
癌症免疫疗法
癌症研究
表观遗传学
肿瘤进展
癌症
细胞代谢
免疫学
细胞
生物化学
遗传学
基因
作者
Weiping Zou,Douglas R. Green
出处
期刊:Cell Metabolism
[Elsevier]
日期:2023-07-01
卷期号:35 (7): 1101-1113
被引量:21
标识
DOI:10.1016/j.cmet.2023.06.003
摘要
Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we review immune-related functions of core metabolic pathways, key metabolites, and crucial nutrient transporters in the TME, discuss their metabolic, signaling, and epigenetic impact on tumor immunity and immunotherapy, and explore how these insights can be applied to the development of more effective modalities to potentiate the function of T cells and sensitize tumor cell receptivity to immune attack, thereby overcoming therapeutic resistance.
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