角质层
脂质体
药物输送
生物利用度
药品
纳米技术
渗透
药理学
材料科学
化学
医学
膜
生物化学
病理
作者
Huma Hameed,Saleha Faheem,Mahtab Ahmad Khan,Anam Hameed,Nelofer Ereej,Hafsa Ihsan
标识
DOI:10.1080/02652048.2024.2326085
摘要
Ethosomes, which are liposomes like structures, mainly composed primarily of ethanol, have attracted considerable attention due to their potential to enhance the drug permeation via skin. The article discusses the formulation and preparation methods of ethosomes, offering insights into the various factors that influence their size, shape, and stability. Moreover, it explores the techniques used to assess the physicochemical properties of ethosomes and their impact on drug delivery effectiveness. The article also elucidates the mechanism by which ethosomes enhance skin permeation, emphasising their ability to modify the lipid structure and fluidity of the stratum corneum. Additionally, the review investigates the applications of ethosomes in diverse drug delivery scenarios, including the delivery of small molecules, peptides, and phytoconstituents. It highlights the potential of ethosomes to improve drug bioavailability, extend drug release, and achieve targeted delivery to specific skin layers or underlying tissues.
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