The use of partially pregelatinized starch from cassava as disintegrant

The use of partially pregelatinized starch in tablet formulations is quite extensive, one of them is a disintegrant agent. The sources of starch are also very broad, including cassava which is quite abundant in Indonesia. The purpose of this study was to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study 7 formulas were used with different disintegrants, 3 formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, and 3 formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and 1 control formula without disintegrant. The experimental design used was a Randomized Block Design. The tablet is made using a wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, the compatibility of partially pregelatinized starch from cassava was carried out and compared with avicel, starch 1500, and cassava starch. The results showed that partially pregelatinized starch from cassava-produced tablets tended to be capping with less hardness than tablets with starch 1500 and control tablets. The compatibility test showed that partially pregelatinized starch from cassava was better than starch 1500 and cassava starch. The disintegration test showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas.