末端脱氧核苷酸转移酶
入射(几何)
医学
淋巴细胞白血病
内科学
精确检验
回顾性队列研究
癌症
肿瘤科
白血病
标记法
免疫组织化学
光学
物理
作者
M Vacek,Luciano Vargas,Elizabeth González Domínguez,Lilia Garcia Rodriguez,Omar A. Tello Teran,Carlos Mojica Cardoso,Luisa Valeria Ocampo Roosens,Juan José Acevedo‐Fernández,Weijie Li,Brian Lee,Jesús Santa-Olalla Tapia,Terrie Flatt
出处
期刊:Journal of Pediatric Hematology Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-12-22
卷期号:46 (2): e131-e136
标识
DOI:10.1097/mph.0000000000002802
摘要
Mexican and Hispanic children in Mexico and the United States, respectively, have the highest incidence and worst outcomes of pre-B acute lymphoblastic leukemia (ALL) compared with other racial/ethnic groups. Terminal deoxynucleotidyl transferase (TdT) is an intranuclear DNA polymerase normally present on immature lymphocytes (TdT-positive) and distinguishes ALL from mature lymphoid malignancies. We performed a multisite retrospective study to determine the incidence of TdT-negative precursor B-cell acute lymphoblastic leukemia (pre-B ALL) among Mexican, Caucasian, and US-born Hispanic children to correlate TdT expression with patient characteristics and known prognostic factors. Fisher exact test was performed for categorical variables and the Wilcoxon rank-sum test was used for continuous variables. TdT-negative pre-B ALL was most frequently identified in patients with National Cancer Institute high-risk disease ( P =0.014). TdT-negative expression was also most frequently associated with hypodiploid pre-B ALL ( P =0.001) and KMT2A gene rearrangement ( P =0.0012). Mexican children had the highest incidence of TdT-negative ALL compared with Caucasians and US Hispanics ( P <0.001), with an increased incidence of poor prognostic features as well. This study demonstrates significant differences in TdT-negative expression, genomic alterations, and leukemic ploidy based on race and ethnicity.
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