下调和上调
趋化性
单核细胞
特发性肺纤维化
肺纤维化
转化生长因子
细胞生物学
纤维化
肺泡巨噬细胞
免疫学
巨噬细胞
化学
癌症研究
生物
医学
肺
病理
基因
内科学
体外
受体
生物化学
作者
Carole Y Perrot,Theodoros Karampitsakos,Avraham Unterman,Taylor Adams,Krystin Marlin,Alyssa Arsenault,Amy Zhao,Naftali Kaminski,Gundars Katlaps,Kapilkumar Patel,Debabrata Bandyopadhyay,José D. Herazo-Maya
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2024-01-08
标识
DOI:10.1152/ajpcell.00563.2023
摘要
Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is higher in Idiopathic Pulmonary Fibrosis (IPF) patients with increased risk of death. Here we aimed to establish the mechanistic role of MCEMP1 in pulmonary fibrosis. We identified increased MCEMP1 expression in classical monocytes and alveolar macrophages in IPF compared to controls. MCEMP1 was upregulated by TGFβ at the mRNA and protein levels in THP-1. TGFβ-mediated MCEMP1 upregulation results from the cooperation of SMAD3 and SP1 via concomitant binding to SMAD3/SP1 cis-regulatory elements within the MCEMP1 promoter. We also found that MCEMP1 regulates TGFβ-mediated monocyte chemotaxis, adhesion, and migration. Our results suggest that MCEMP1 may regulate the migration and transition of monocytes to monocyte-derived alveolar macrophages during pulmonary fibrosis development and progression.
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