透明软骨
软骨
髋臼
透明质
纤维软骨
股骨头
解剖
医学
软骨内骨化
H&E染色
髋关节发育不良
阿格里坎
病理
免疫组织化学
关节软骨
骨关节炎
射线照相术
外科
替代医学
作者
Tea Duvančić,Andreja Vukasović Barišić,Ana Čizmić,Mihovil Plečko,Ivan Bohaček,Domagoj Delimar
出处
期刊:Diagnostics
[MDPI AG]
日期:2024-04-08
卷期号:14 (7): 779-779
标识
DOI:10.3390/diagnostics14070779
摘要
Developmental dysplasia of the hip (DDH) presents varying degrees of femoral head dislocation, with severe cases leading to the formation of a new articular surface on the external side of the iliac bone-the neoacetabulum. Despite conventional understanding suggesting otherwise, a tissue resembling hyaline cartilage is found in the neoacetabulum and acetabulum of Crowe III and IV patients, indicating a potential for hyaline cartilage development without mechanical pressure. To test this theory, acetabular and femoral head cartilage obtained from patients with DDH was stained with hematoxylin-eosin and toluidine blue. The immunohistochemical analysis for collagen types II and VI and aggrecan was performed, as well as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) analysis on a 7.0 T micro-MRI machine. The results obtained from DDH patients were compared to those of the control groups. Hyaline cartilage was found in the neoacetabulum and the acetabulum of patients with DDH. The nature of the tissue was confirmed with both the histological and the MRI analyses. The results of this study proved the presence of hyaline cartilage in patients with DDH at anatomical regions genetically predisposed to be bone tissue and at regions that are not subjected to mechanical stress. This is the first time that the neoacetabular cartilage of patients with advanced stages of DDH has been characterized in detail.
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