免疫监视
肺
医学
抗生素治疗
抗生素
益生菌
免疫学
免疫系统
肺脓肿
肠道菌群
生物
微生物学
内科学
细菌
遗传学
作者
Valentino Le Noci,Simone Guglielmetti,Stefania Arioli,Chiara Camisaschi,Francesca Bianchi,Michele Sommariva,Chiara Storti,Tiziana Triulzi,Chiara Castelli,Andrea Balsari,Elda Tagliabue,Lucia Sfondrini
出处
期刊:Cell Reports
[Cell Press]
日期:2018-09-01
卷期号:24 (13): 3528-3538
被引量:180
标识
DOI:10.1016/j.celrep.2018.08.090
摘要
Highlights•Aerosolized antibiotic reduces lung microbiota and a tolerogenic microenvironment•Aerosol delivery of an antibiotic or probiotic decreases tumor seeding in the lung•Antibiotic or probiotic aerosol improves chemotherapy against experimental metastasesSummaryPulmonary immunological tolerance to inhaled particulates might create a permissive milieu for lung metastasis. Lung microbiota contribute to pulmonary tolerance; here, we explored whether its manipulation via antibiotic or probiotic aerosolization favors immune response against melanoma metastasis. In lungs of vancomycin/neomycin-aerosolized mice, a decrease in bacterial load was associated with reduced regulatory T cells and enhanced T cell and NK cell activation that paralleled a significant reduction of melanoma B16 lung metastases. Reduction of metastases also occurred in lungs transplanted with bacterial isolates from antibiotic-treated lungs. Aerosolized Lactobacillus rhamnosus strongly promoted immunity against B16 lung metastases as well. Furthermore, probiotics or antibiotics improved chemotherapy activity against advanced B16 metastases. Thus, we identify a role for lung microbiota in metastasis and show that its targeting via aerosolization is a therapy that can prevent metastases and enhance responses to chemotherapy.Graphical abstract
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