亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Changes in body composition and prognostic importance of sarcopenia in patients receiving CTRT for oropharyngeal cancer.

医学 肌萎缩 比例危险模型 大腿 瘦体质量 内科学 回顾性队列研究 大腿内侧室 体质指数 胃肠病学 泌尿科 外科 体重
作者
Shrujal S. Baxi,Lee W. Jones,Anne Eaton,Stephanie Gandelman,Darragh Halpenny,Jasmyne Jackson,Rachel Kurtzman,Sean McBride,Andrew J. Plodkowski,David G. Pfister
出处
期刊:Journal of Clinical Oncology [Lippincott Williams & Wilkins]
卷期号:34 (15_suppl): 6077-6077 被引量:3
标识
DOI:10.1200/jco.2016.34.15_suppl.6077
摘要

6077 Background: Concurrent chemoradiation (CTRT) improves outcomes in oropharyngeal cancer (OPC) but causes toxicities that alter body composition. In other cancers, loss of lean body mass (sarcopenia) is associated with poor prognosis. Changes in body composition in OPC, and the clinical importance of these alterations, have not been studied. Methods: Using a retrospective design, 234 OPC patients (mean age, 58 years (range 27 to 83); mean BMI, 29 kg/m2) receiving definitive CTRT were studied. Skeletal muscle cross-sectional area (CSA) at the third lumbar vertebra (L3) and thigh were assessed by CT-scan prior to and after completion of CTRT (median: 13.5 wks; range 2-27) and normalized to stature to obtain skeletal muscle index (cm2/m2). Sarcopenia was defined using previously published cutoffs. Cox models were used to assess the relationship between sarcopenia and recurrence-free survival (RFS) and overall survival (OS). Wilcoxon rank-sum tests were used to assess changes in percent loss in weight and L3 and thigh muscle CSA in patients hospitalized post-CTRT. Results: Prior to CTRT, 68% of patients were classified as sarcopenic. HPV-testing was completed in 168 (72%); 149 were positive. Post-CTRT, body mass (kg) decreased a median of 13.8% (IQR: 10.1% to 18.7%, p < .001) while muscle CSA at L3 and thigh decreased by 11.2% (IQR: 6.9% to 16.8%, p < .001) and 13.6% (IQR: 5.5% to 21.2%, p < .001), respectively; 89% were classified as sarcopenic. Older age and male were significant baseline predictors of sarcopenia post-CTRT (p’s < 0.05). Fifty-eight (25%) patients were hospitalized within 3 months of CTRT. Median follow-up was 34 months; in this period, 26 recurrences and 19 deaths were observed. Greater percent weight loss and thigh muscle CSA loss were positively associated with risk of hospitalization (p’s < 0.01); baseline or post-treatment sarcopenia were not associated with RFS or OS (p’s > 0.05). Conclusions: A significant proportion of OPC patients present with clinical sarcopenia, while CTRT increases the proportion of subjects with this condition.Decreases in body and muscle mass are associated with hospitalization. The long-term clinical impact of these losses remains to be determined.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李李发布了新的文献求助10
5秒前
科研通AI5应助李李采纳,获得10
12秒前
爱笑的毛衣完成签到,获得积分10
14秒前
太叔丹翠完成签到 ,获得积分10
16秒前
沉默白猫完成签到 ,获得积分10
17秒前
21秒前
sowhat完成签到 ,获得积分10
24秒前
孙老师完成签到 ,获得积分10
29秒前
盛事不朽完成签到 ,获得积分10
29秒前
31秒前
科研通AI2S应助科研通管家采纳,获得10
32秒前
FashionBoy应助科研通管家采纳,获得10
32秒前
羞涩的傲菡完成签到,获得积分10
44秒前
44秒前
Hung发布了新的文献求助10
49秒前
56秒前
Lyncon完成签到,获得积分10
1分钟前
Milton_z完成签到 ,获得积分0
1分钟前
Hung完成签到,获得积分10
1分钟前
tingyeh完成签到,获得积分10
1分钟前
1分钟前
两个我完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
务实书包完成签到,获得积分10
1分钟前
1分钟前
2分钟前
2分钟前
英姑应助科研通管家采纳,获得10
2分钟前
打打应助科研通管家采纳,获得10
2分钟前
2分钟前
24124f发布了新的文献求助10
2分钟前
2分钟前
2分钟前
3分钟前
大闲鱼铭一完成签到 ,获得积分10
3分钟前
干净涵梅发布了新的文献求助10
3分钟前
舒适的藏花完成签到 ,获得积分10
3分钟前
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990049
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256354
捐赠科研通 3270976
什么是DOI,文献DOI怎么找? 1805166
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228