Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study

医学 优势比 胎龄 人口 小于胎龄 阿普加评分 产科 高龄产妇 妊娠期糖尿病 儿科 出生体重 新生儿重症监护室 置信区间 低出生体重 早产 怀孕 队列研究 队列 妊娠期 胎儿 内科学 环境卫生 生物 遗传学
作者
Yash S. Khandwala,Valerie L. Baker,Gary M. Shaw,David K. Stevenson,Ying Lü,Michael L. Eisenberg
出处
期刊:BMJ [BMJ]
卷期号:: k4372-k4372 被引量:160
标识
DOI:10.1136/bmj.k4372
摘要

To evaluate the impact of advanced paternal age on maternal and perinatal outcomes in the United States.Retrospective, population based cohort study.US.40 529 905 documented live births between 2007 and 2016.Primary perinatal outcomes were gestational age, birth weight, Apgar score at five minutes, admission to a neonatal intensive care unit, need for postpartum antibiotics, and seizures. Primary maternal outcomes were gestational diabetes and pre-eclampsia. Secondary outcome was the number of preventable perinatal events.Higher paternal age was associated with an increased risk of premature birth, low birth weight, and low Apgar score. After adjustment for maternal age, infants born to fathers aged 45 years or older had 14% higher odds of premature birth (odds ratio 1.14, 95% confidence interval 1.13 to 1.15), independent of gestational age, and 18% higher odds of seizures (1.18, 0.97 to 1.44) compared with infants of fathers aged 25 to 34 years. The odds of gestational diabetes was 34% higher (1.34, 1.29 to 1.38) in mothers with the oldest partners. 13.2% (95% confidence interval 12.5% to 13.9%) of premature births and 18.2% (17.5% to 18.9%) of gestational diabetes in births associated with older fathers were estimated to be attributable to advanced paternal age.Advanced paternal age is associated with negative effects on both mothers and offspring. Given the relatively low prevalence of advanced paternal age in the US, population level impacts are currently modest. Nevertheless, as advanced paternal age has doubled in the US over the past generation, further investigation is warranted of the impact on birth outcomes and public health.
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