甲状腺机能正常
内科学
内分泌学
自身免疫
格雷夫斯病
医学
受体
外围设备
病理生理学
外周血
疾病
甲状腺
作者
Katarzyna Strawa,Anna Markowska,Piotr Miśkiewicz,Aleksander Kuś,Urszula Ambroziak,Konrad Szymański,Renata Zbiec,Magdalena Spólnicka,Paweł Krajewski,Tomasz Bednarczuk,Rafał Płoski
摘要
Summary Background T‐cell receptor rearrangement excision circles ( TREC ) are circular DNA molecules generated during T‐cell maturation in the thymus. Recent studies suggested that a decreased TREC concentration in peripheral blood may be a general feature of autoimmunity. Our purpose was to assess the TREC concentration in Graves' disease ( GD ). Methods TREC concentration was assessed by real time PCR in DNA samples isolated from peripheral blood leucocytes among younger ( n = 94, age range 6–29 years) and older patients with GD ( n = 93, age range 57–80 years) and age‐matched controls ( n = 206). Results TREC concentration decreased with age in all subjects, but it was significantly higher in GD compared with controls ( P = 9·4 × 10 −10 ). TREC concentration was higher ( P = 0·0038) in hyperthyroid ( n = 78) than euthyroid ( n = 82) patients with GD , but in both groups, it remained increased relative to controls ( P = 2·2 × 10 −11 and P = 4·4 ×10 −7 , respectively). Conclusions Patients with GD , particularly those with hyperthyroidism, have increased concentration of TREC which may suggest increased rather than decreased thymic activity. Thus, GD does not follow the paradigm suggested for other autoimmune disorders which links autoimmunity with thymic senescence.
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