光热治疗
阿霉素
材料科学
碳纳米管
癌细胞
程序性细胞死亡
光热效应
细胞
生物物理学
细胞凋亡
纳米技术
癌症
癌症研究
化疗
医学
化学
生物化学
生物
外科
内科学
作者
Yunok Oh,Jun‐O Jin,Junghwan Oh
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2017-02-23
卷期号:28 (12): 125101-125101
被引量:35
标识
DOI:10.1088/1361-6528/aa5d7d
摘要
Single-walled carbon nanotubes (SWNTs) are often the subject of investigation as effective photothermal therapy (PTT) agents owing to their unique strong optical absorption. Doxorubicin (DOX)-loaded SWNTs (SWNTs-DOX) can be used as an efficient therapeutic agent for combined near infrared (NIR) cancer photothermal and chemotherapy. However, SWNTs-DOX-mediated induction of cancer cell death has not been fully investigated, particularly the reaction of DOX inside cancer cells by PTT. In this study, we examined how the SWNTs-DOX promoted effective MDA-MB-231 cell death compared to DOX and PTT alone. We successfully synthesized the SWNTs-DOX. The SWNTs-DOX exhibited a slow DOX release, which was accelerated by NIR irradiation. Furthermore, DOX released from the SWNTs-DOX accumulated inside the cells at high concentration and effectively localized into the MDA-MB-231 cell nucleus. A combination of SWNTs-DOX and PTT promoted an effective MDA-MB-231 cell death by mitochondrial disruption and ROS generation. Thus, SWNTs-DOX can be utilized as an excellent anticancer agent for early breast cancer treatment.
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