亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Thyroid Function Characteristics and Determinants: The Rotterdam Study

鹿特丹研究 医学 甲状腺功能 体质指数 甲状腺过氧化物酶 甲状腺 内科学 内分泌学 人口 甲状腺功能测试 队列研究 人口学 环境卫生 社会学
作者
Layal Chaker,Tim I.M. Korevaar,Marco Medici,André G. Uitterlinden,Albert Hofman,Abbas Dehghan,Oscar H. Franco,Robin P. Peeters
出处
期刊:Thyroid [Mary Ann Liebert]
卷期号:26 (9): 1195-1204 被引量:87
标识
DOI:10.1089/thy.2016.0133
摘要

Background: Information on determinants and change of thyroid function over time is sparse and conflicting but crucial for clinical interpretation and research. Therefore, our aim was to systematically investigate determinants of thyroid-stimulating hormone (TSH), free thyroxine (FT4) (as markers of thyroid function), their mutual relation (as marker of thyroid function set point) and changes in thyroid function over time. Methods: We included 9402 participants from the Rotterdam Study not taking thyroid medication and with available thyroid function measurements. Repeated measurements (6.5-year interval) were available for 1225 participants. The association of selected determinants with TSH, FT4, and their mutual relation (reflecting thyroid function set point) was estimated using linear regression models using restricted cubic splines with three knots. The factors investigated were age, sex, body mass index (BMI), tobacco smoking, alcohol use, thyroperoxidase antibodies (TPOAb), and common genetic factors. Results: Most influential determinants of TSH were age, smoking, genetic determinants, and TPOAb levels (p < 0.001). For FT4, most influential determinants were age, BMI, sex, genetic determinants and TPOAb levels (p < 0.001). Older age, female sex, and increased TPOAb levels were associated with a stronger relation between TSH and FT4. TSH levels did not change over time, irrespective of age. FT4 levels increased over time, most prominently in those older than 65 years of age (mean increase of 4.5 pmol/L). Conclusions: The main factors that influence the relationship between thyroid hormone and molar concentrations of TSH in our population-based cohort study are age, smoking, BMI, TPOAb levels, and common genetic variants. The set point that determines TSH secretion as it relates to negative thyroid hormone feedback is modified by age, sex and TPOAb positivity. FT4 levels increase over time, with a more pronounced increase in the elderly, while TSH values seem stable over time. Our results question the current notion of an increase of TSH with increasing age.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Coffee完成签到 ,获得积分10
5秒前
星辰大海应助科研通管家采纳,获得10
12秒前
斯文败类应助科研通管家采纳,获得10
13秒前
面向杂志编论文应助124332采纳,获得10
16秒前
可爱的函函应助124332采纳,获得10
16秒前
123完成签到 ,获得积分10
21秒前
21秒前
23秒前
dd发布了新的文献求助10
26秒前
天天快乐应助dd采纳,获得10
34秒前
36秒前
卓头OvQ应助辛勤的小海豚采纳,获得10
39秒前
dd完成签到,获得积分10
46秒前
54秒前
汉堡包应助高敏采纳,获得10
58秒前
1分钟前
科研通AI2S应助zjspidany采纳,获得10
1分钟前
zqq完成签到,获得积分0
1分钟前
1分钟前
1分钟前
高敏发布了新的文献求助10
1分钟前
qianchang完成签到,获得积分10
1分钟前
wxl完成签到,获得积分10
1分钟前
搜索v完成签到,获得积分10
1分钟前
双黄应助搜索v采纳,获得20
1分钟前
生动的以云完成签到 ,获得积分10
1分钟前
香蕉觅云应助Nacy采纳,获得10
1分钟前
1分钟前
不想说话完成签到 ,获得积分10
1分钟前
Nacy发布了新的文献求助10
1分钟前
科目三应助zjspidany采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
NexusExplorer应助科研通管家采纳,获得10
2分钟前
2分钟前
Prehye发布了新的文献求助10
2分钟前
Marciu33发布了新的文献求助10
2分钟前
科研通AI2S应助zjspidany采纳,获得10
2分钟前
tiantian完成签到 ,获得积分10
2分钟前
Prehye完成签到,获得积分10
2分钟前
高分求助中
Rock-Forming Minerals, Volume 3C, Sheet Silicates: Clay Minerals 2000
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 930
The Vladimirov Diaries [by Peter Vladimirov] 600
Development of general formulas for bolted flanges, by E.O. Waters [and others] 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3265467
求助须知:如何正确求助?哪些是违规求助? 2905505
关于积分的说明 8333941
捐赠科研通 2575798
什么是DOI,文献DOI怎么找? 1400130
科研通“疑难数据库(出版商)”最低求助积分说明 654702
邀请新用户注册赠送积分活动 633532