癌症研究
促炎细胞因子
癌变
下调和上调
细胞生物学
蛋白激酶B
信号转导
生物
化学
炎症
癌症
免疫学
遗传学
生物化学
基因
作者
Benjamin J. Dwyer,Edward J. Jarman,Jully Gogoi-Tiwari,Sofía Ferreira-González,Luke Boulter,Rachel V. Guest,Timothy J. Kendall,Dominic Kurian,Alastair M. Kilpatrick,Andrew J. Robson,Eoghan O’Duibhir,Tak Yung Man,Lara Campana,Philip J. Starkey Lewis,Stephen J. Wigmore,John K. Olynyk,Grant A. Ramm,Janina E. E. Tirnitz‐Parker,Stuart J. Forbes
标识
DOI：10.1016/j.jhep.2020.11.018
摘要
Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is known to signal via its receptor fibroblast growth factor-inducible 14 (Fn14) and induce cholangiocyte and myofibroblast proliferation in liver injury. We aimed to characterise its role in CCA.
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