磷酸戊糖途径
糖酵解
柠檬酸循环
糖异生
癌细胞
生物
褪黑素
代谢途径
氧化磷酸化
厌氧糖酵解
细胞生长
碳水化合物代谢
生物化学
新陈代谢
细胞周期
癌症
细胞生物学
细胞
内分泌学
遗传学
作者
Carmen Rodrı́guez,Noelia Puente‐Moncada,Russel J. Reıter,Ana M. Sánchez‐Sánchez,Federico Herrera,Jezabel Rodríguez‐Blanco,Cristina Duarte‐Olivenza,María Turos‐Cabal,Isaac Antolı́n,Vanesa Martı́n
摘要
Abstract Several oncogenic pathways plus local microenvironmental conditions, such as hypoxia, converge on the regulation of cancer cells metabolism. The major metabolic alteration consists of a shift from oxidative phosphorylation as the major glucose consumer to aerobic glycolysis, although most of cancer cells utilize both pathways to a greater or lesser extent. Aerobic glycolysis, together with the directly related metabolic pathways such as the tricarboxylic acid cycle, the pentose phosphate pathway, or gluconeogenesis are currently considered as therapeutic targets in cancer research. Melatonin has been reported to present numerous antitumor effects, which result in a reduced cell growth. This is achieved with both low and high concentrations with no relevant side effects. Indeed, high concentrations of this indolamine reduce proliferation of cancer types resistant to low concentrations and induce cell death in some types of tumors. Previous work suggest that regulation of glucose metabolism and other related pathways play an important role in the antitumoral effects of high concentration of melatonin. In the present review, we analyze recent work on the regulation by such concentrations of this indolamine on aerobic glycolysis, gluconeogenesis, the tricarboxylic acid cycle and the pentose phosphate pathways of cancer cells.
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