Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls

医学 长期变化 乳房发育 人口学 儿科 内科学 激素 社会学
作者
Camilla Eckert‐Lind,Alexander S. Busch,Jørgen Holm Petersen,Frank M. Biro,Gary Butler,Elvira V. Bräuner,Anders Juul
出处
期刊:JAMA Pediatrics [American Medical Association]
卷期号:174 (4): e195881-e195881 被引量:296
标识
DOI:10.1001/jamapediatrics.2019.5881
摘要

Importance

The initial clinical sign of pubertal onset in girls is breast gland development (thelarche). Although numerous studies have used recalled age at menarche (first menstruation) to assess secular trends of pubertal timing, no systematic review has been conducted of secular trends of thelarche.

Objectives

To systematically evaluate published data on pubertal timing based on age at thelarche and evaluate the change in pubertal onset in healthy girls around the world.

Data Sources

A systematic literature search was performed in PubMed and Embase of all original peer-reviewed articles published in English before June 20, 2019.

Study Selection

Included studies used clinical assessment of breast development in healthy girls and used adequate statistical methods, including the reporting of SEs or CIs. The quality of the articles was evaluated by assessing study design, potential sources of bias, main characteristics of the study population, and methods of statistical analysis.

Data Extraction and Synthesis

In accordance with PRISMA guidelines, all articles were assessed for eligibility independently by 2 authors. Weighted regression analysis was performed using a random-effects model.

Main Outcomes and Measures

Studies examining age at thelarche (development of Tanner breast stage 2) in healthy girls.

Results

The literature search resulted in a total of 3602 studies, of which 30 studies fulfilled the eligibility criteria. There was a secular trend in ages at thelarche according to race/ethnicity and geography. Overall, the age at thelarche decreased 0.24 years (95% CI, −0.44 to −0.04) (almost 3 months) per decade from 1977 to 2013 (P = .02).

Conclusions and Relevance

The age at thelarche has decreased a mean of almost 3 months per decade from 1977 to 2013. A younger age at pubertal onset may change current diagnostic decision-making. The medical community needs current and relevant data to redefine "precocious puberty," because the traditional definition may be outdated, at least in some regions of the world.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yang发布了新的文献求助10
1秒前
orixero应助zzzzzbbl采纳,获得10
2秒前
wzy4319关注了科研通微信公众号
2秒前
4秒前
imcwj完成签到 ,获得积分10
6秒前
赘婿应助沉静紫安采纳,获得10
8秒前
所所应助孔雀翎采纳,获得10
8秒前
FSYHantis完成签到,获得积分10
8秒前
仚屳发布了新的文献求助10
9秒前
科研通AI5应助888采纳,获得10
9秒前
11秒前
12秒前
Jasper应助王珺采纳,获得10
12秒前
yang发布了新的文献求助10
13秒前
慕青应助一一采纳,获得10
14秒前
小二郎应助灰灰采纳,获得10
14秒前
Layace发布了新的文献求助10
15秒前
彳亍完成签到 ,获得积分10
15秒前
16秒前
wzy4319发布了新的文献求助10
16秒前
四文鱼发布了新的文献求助10
16秒前
baibaibai完成签到,获得积分10
17秒前
20秒前
郑qqqq发布了新的文献求助10
21秒前
22秒前
23秒前
25秒前
微信研友发布了新的文献求助10
25秒前
希望天下0贩的0应助张三采纳,获得10
25秒前
搜集达人应助郑qqqq采纳,获得10
27秒前
不懈奋进应助白羽佳采纳,获得30
27秒前
28秒前
28秒前
suuri发布了新的文献求助10
30秒前
大个应助大龙哥886采纳,获得10
30秒前
所所应助ZZXX采纳,获得10
30秒前
32秒前
32秒前
豆子发布了新的文献求助10
33秒前
ytolll发布了新的文献求助10
33秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3542895
求助须知:如何正确求助?哪些是违规求助? 3120176
关于积分的说明 9341944
捐赠科研通 2818272
什么是DOI,文献DOI怎么找? 1549447
邀请新用户注册赠送积分活动 722160
科研通“疑难数据库(出版商)”最低求助积分说明 712978