Progress in the development of common experimental animal models of the eye neoplasm and the orbital diseases

The eye neoplasm and the orbital diseases are a class of serious illness which will cause visual function damage and even life threatening. At present, the etiology and pathogenesis of the most eye neoplasm and orbital diseases are still not clear, which has an adverse effect on the treatment. The medical experimental animal models are the ideal model to simulate human diseases. At the same time, the establishment of related animal models with the eye neoplasm and the orbital diseases is a helpful aid in getting to know the etiology and pathogenesis, providing a basis for studying the etiology and pathogenesis of these diseases. Some progress has been achieved some progress in recent years, however, compared to other diseases, the related animal models of these are still few. The progress in the common experimental animal models of the eye neoplasm and the orbital diseases, the animal models of the thyroid-associated ophthalmopathy (TAO), the orbital adenoid cystic carcinoma, the retinoblastoma (RB), the uveal melanoma, and the idiopathic orbital inflammatory pseudotumor were reviewed in this article. Key words: Eye neoplasm; Orbital diseases; Animal model/experimental