缺血
再灌注损伤
自噬
心肌梗塞
医学
病理生理学
氧化应激
炎症
生物信息学
长非编码RNA
细胞凋亡
基因
生物
心脏病学
病理
免疫学
内科学
核糖核酸
遗传学
作者
Zhuo Zhao,Weiyi Sun,Ziyuan Guo,Bin Liu,Hongyu Yu,Jichang Zhang
摘要
Following an acute myocardial infarction, reperfusion therapy is currently the most effective way to save the ischemic myocardium; however, restoring blood flow may lead to a myocardial ischemia-reperfusion injury (MIRI). Recent studies have confirmed that long-chain noncoding RNAs (LncRNAs) play important roles in the pathophysiology of MIRIs. These LncRNA-mediated roles include cardiomyocyte apoptosis, autophagy, necrosis, oxidative stress, inflammation, mitochondrial dysfunction, and calcium overload, which are regulated through the expression of target genes. Thus, LncRNAs may be used as clinical diagnostic markers and therapeutic targets to treat or prevent MIRI. This review evaluates the research on LncRNAs involved in MIRIs and provides new ideas for preventing and treating this type of injury.
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