微小变化病
不利影响
医学
肾病综合征
疾病
内科学
肾小球肾炎
局灶节段性肾小球硬化
肾
作者
Abbal Koirala,Jeffrey B. Kopp
出处
期刊:Glomerular diseases
[S. Karger AG]
日期:2021-07-29
卷期号:1 (4): 237-249
被引量:1
摘要
Minimal change disease (MCD) causes approximately 10% of nephrotic syndrome in adults. While glucocorticoids (GCs) effectively induce remission in MCD, the disease has a high relapse rate (50-75%), and repeated exposure to GCs is often required. The adverse effects of GCs are well recognized and commonly encountered with the high doses and recurrent courses used in MCD.In this review, we will discuss the standard therapy of MCD in adults and then describe new therapeutic options in induction therapy and treatment of relapses in MCD, minimizing the exposure to GCs.Steroid minimization strategies may decrease adverse effects in the treatment of MCD.
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