Non-thermal ablation of rabbit liver VX2 tumor by pulsed high intensity focused ultrasound with ultrasound contrast agent: Pathological characteristics

group, with cytoplasmic vacuoles of various sizes, chromatin margination and karyopyknosis.Electron microscopic examination revealed tumor cell volume reduction, karyopyknosis, chromatin margination, intercellular space widening, the presence of high electron-density apoptotic bodies and vacuoles in cytoplasm. CONCLUSION:The non-thermal effects of PHIFU combined with UCA can be used to ablate rabbit liver VX2 tumors.