Synthesis of 3,6‐Disubstituted 4‐Ethoxycarbonylpyranoindol‐1‐ones Utilizing 3‐Amino‐2‐pyrone Synthesis

Abstract Synthesis of 3,6‐disubstituted 4‐ethoxycarbonylpyranoindol‐1‐ones is developed using palladium‐catalyzed intramolecular amination of 3‐amino‐4‐(2‐bromophenyl)‐2‐pyrones prepared by the conjugate addition reaction of diethyl 2‐aminomalonate to alkynyl ketones. The transformation of the synthesized 3‐amino‐4‐(2‐bromophenyl)‐2‐pyrones via palladium‐catalyzed intramolecular amination afforded 3,6‐disubstituted 4‐ethoxycarbonylpyranoindol‐1‐ones.