The Potential of Graphene Oxide and Reduced Graphene Oxide in Diagnosis and Treatment of Cancer

Nanotechnology is a pioneer field of study; for engineering smart nanosystems in targeted diagnosis and treatment in cancer therapy. The potent therapy for different kinds of solid tumors should ideally target individually the cancerous cells and tissue with no impact on healthy cells in the body. Nano-sized graphene oxide (GO) and reduced graphene oxide (rGO) have phenomenal chemical versatility, high surface area ratio, and supernatural physical properties. The synergistic effects caused by the well-defined assembly of GO and rGO surface generate not only essential optical, mechanical, but also electronic behaviors. Developing novel multifunctional hybrid nanoparticles with great potential is highly considered in multimodal cancer treatment. GO, and rGO are engineered as a programmable targeting delivery system and combed with photonic energy they utilize in photothermal therapy. Its remarkable properties indicated its applications as a biosensor, bio-imaging for cancer diagnosis. In this current review, we show a remarkable highlight about GO, rGO, and discuss the notable applications for cancer diagnosis and treatment, and an overview of possible cellular signaling pathways that are affected by GO, rGO in cancer treatment.