We report a case of a man in his 50s who developed open-angle glaucoma following neodymium-doped yttrium aluminium garnet (YAG) laser vitreolysis. Despite attempts to control the pressure with topical medication and selective laser trabeculoplasty (SLT), surgical intervention using a Baerveldt glaucoma valve (BGV) was needed after which the intraocular pressure was controlled successfully. This rare but serious complication highlights the fact that in certain cases long-term monitoring of intraocular pressure is necessary following laser vitreolysis.