This chapter contains sections titled: Apolipoproteins Lipoproteins Apo A-containing lipoproteins Apo B-containing lipoproteins Apolipoproteins C, D, and E The triglyceride lipase family The normal metabolism of free fatty acids Inflammation and hepatic insulin resistance Atherogenic dyslipidemia in insulin resistance Lipid-lowering therapy The HMG CoA reductase inhibitors Nicotinic acid The fibric acid derivatives Bile acid sequestrants Ezetimibe CETP inhibition Conclusion Bibliography