前列腺癌
细胞生长
癌症研究
细胞周期
E2F型
癌症
癌细胞
生物
遗传学
作者
Lin Huang,Keng Chen,Zhaopeng Cai,Fuchao Chen,Huiyong Shen,Weihua Zhao,Song-jie Yang,Xu-biao Chen,Guoxue Tang,Xi Lin
标识
DOI:10.1016/j.bbrc.2017.06.105
摘要
DEP domain containing 1 (DEPDC1) is recently reported to be overexpressed in several types of human cancer; however the role of DEPDC1 in prostate cancer remains to be investigated. Herein, we identified that the DEPDC1 mRNA and protein expression levels were dramatically increased in prostate cancer tissues and cell lines. Overexpression of DEPDC1 promoted, but depletion of DEPDC1 inhibited cell proliferation by regulating the G1-S phase cell cycle transition. Importantly, we found that DEPDC1 was essential for the tumor growth and formation of bone metastases of prostate cancer cells in vivo. Finally, we demonstrated that DEPDC1 interacted with E2F1 and increased its transcriptional activity, leading to hyper-activation of E2F signaling in prostate cancer cells. Our findings reveal an oncogenic role of DEPDC1 in prostate cancer progression via activation of E2F signaling, and suggest DEPDC1 might be a potential therapeutic target against the disease.
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