滑液
蛋白质组学
生物标志物发现
关节炎
蛋白质组
骨关节炎
银屑病性关节炎
医学
生物标志物
滑膜
软骨
计算生物学
生物信息学
生物
病理
免疫学
生物化学
基因
解剖
替代医学
作者
Shalini Mahendran,Κατερίνα Οικονομοπούλου,Eleftherios P. Diamandis,Vinod Chandran
标识
DOI:10.1080/10408363.2017.1408561
摘要
Synovial fluid (SF) is a protein-rich fluid produced into the joint cavity by cells of the synovial membrane. Due to its direct contact with articular cartilage, surfaces of the bone, and the synoviocytes of the inner membrane, it provides a promising reflection of the biochemical state of the joint under varying physiological and pathophysiological conditions. This property of SF has been exploited within numerous studies in search of unique biomarkers of joint pathologies with the ultimate goal of developing minimally invasive clinical assays to detect and/or monitor disease states. Several proteomic methodologies have been employed to mine the SF proteome. From elementary immunoassays to high-throughput analyses using mass spectrometry-based techniques, each has demonstrated distinct advantages and disadvantages in the identification and quantification of SF proteins. This review will explore the role of SF in the elucidation of the arthritis proteome and the extent to which high-throughput techniques have facilitated the discovery and validation of protein biomarkers from osteoarthritis (OA), rheumatoid arthritis (RA), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA) patients.
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