HBx公司
肝细胞癌
癌症研究
乙型肝炎病毒
抑制器
生物
蛋白激酶B
信号转导
蛋白质酪氨酸磷酸酶
癌症
病毒
免疫学
遗传学
生物化学
作者
Zhenyu Zhou,Wei Yu,Huoming Li,Juanyi Shi,Shaowu Meng,Yongcong Yan,R. Chen,H. Liu,Jie Wang,Jiantong Sun,Zengming Xiao,J Zhang
标识
DOI:10.1158/1541-7786.mcr-23-0696
摘要
Abstract HBV-associated hepatocellular carcinoma (HCC) represents the prevalent form of HCC, with HBx protein being a crucial oncoprotein. Numerous members of the protein tyrosine phosphatase non-receptor (PTPN) family have been confirmed to be significantly associated with the occurrence and progression of malignant tumors. Our group has previously identified the involvement of PTPN13 in HCC. However, the roles of other PTPNs in HCC still requires further investigation. In this study, we found PTPN18 expression was significantly downregulated within HCC tissues compared to that in adjacent non-tumor tissues and normal liver tissues. Functionally, PTPN18 exerted inhibitory effects on the proliferation, migration, invasion, and sphere-forming capability of HCC cells, while concurrently promoting apoptotic processes. Through phospho-protein microarray screening followed by subsequent validation experiments, we identified that PTPN18 could activate the p53 signaling pathway and suppress the AKT/FOXO1 signaling cascade in HCC cells. Moreover, we found that the HBx protein mediated the repression of PTPN18 expression by upregulating miR-128-3p. Collectively, our study unveiled the role of PTPN18 as a tumor suppressor in HBV-related HCC. Implications: Our findings revealed PTPN18 might serve as a potential diagnostic and therapeutic target for HBV-related HCC.
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