透明质酸
儿茶酚
粘附
自愈水凝胶
化学
高分子化学
化学工程
高分子科学
材料科学
生物物理学
有机化学
解剖
工程类
医学
生物
作者
Fan Yang,Yunlu Chen,Wentao Zhang,Shaochun Gu,Zhenjie Liu,M Chen,Leidan Chen,Feng Chen,Huicong Zhang,Yude Ding,Yanshan Liu,Jinyi Chen,Lınhong Wang
标识
DOI:10.1016/j.ijbiomac.2024.132119
摘要
Hyaluronic acid-based hydrogels have been broadly used in medical applications due to their remarkable properties such as biocompatibility, biodegradability, super hydroscopicity, non-immunogenic effect, etc. However, the inherent weak and hydrophilic polysaccharide structure of pure hyaluronic acid (HA) hydrogels has limited their potential use in muco-adhesiveness, wound dressing, and 3D printing. In this research, we developed in-situ forming of catechol-modified HA hydrogels with improved mechanical properties involving blue-light curing crosslinking reaction. The effect of catechol structure on the physicochemical properties of HA hydrogels was evaluated by varying the content (0-40 %). The as-synthesized hydrogel demonstrated rapid prototyping, excellent wetting adhesiveness, and good biocompatibility. Furthermore, an optimized hydrogel precursor solution was used as a blue light-cured bio-ink with high efficiency and good precision and successfully prototyped a microstructure that mimicked the human hepatic lobule by using DLP 3D printing method. This catechol-modified HA hydrogel with tunable physicochemical and rapid prototyping properties has excellent potential in biomedical engineering.
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