透皮
纳米技术
材料科学
药物输送
生物医学工程
计算机科学
医学
药理学
作者
Guangzhi Gao,Li Zhang,Zhipeng Li,Shichao Ma,Fengsen Ma
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2022-12-07
卷期号:9 (1): 85-105
被引量:12
标识
DOI:10.1021/acsbiomaterials.2c01123
摘要
The use of microneedles (MNs), an innovative transdermal technology, enables efficient, convenient, painless, and controlled-release drug delivery. Porous microneedles (pMNs), special MNs with abundant interconnected pores that can produce capillary action, are gaining increasing attention as a novel MNs technology. pMNs can actively adsorb bioactive ingredients from solutions of drugs or vaccines for in vivo delivery or from interstitial skin fluids (ISFs) for wearable and point-of-care testing (POCT) products. Different pore sizes and porosities of pMNs can be achieved with different materials and preparation processes, which makes the application of pMNs adaptable to multiple scenarios. In addition, easier and faster detection will be accomplished by the smart combination of pMNs with other detection technologies. This paper aims to summarize the recent research progress of pMNs, focusing on the influence of various materials and their corresponding preparation methods on its structure and function display, discussing the key issues and looking forward to the future development.
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