DNA甲基化
生物
表观遗传学
甲基化
基因组印记
遗传学
发育生物学
基因
衰老
进化生物学
基因表达
作者
Ake T. Lu,Zhe Fei,Amin Haghani,Todd R. Robeck,Joseph A. Zoller,Caesar Z. Li,Robert Lowe,Qi Yan,Joshua Zhang,Hoang‐Giang Vu,Julia Ablaeva,Victoria A. Acosta-Rodríguez,Danielle M. Adams,Javier Almunia,Ajoy Aloysius,Reza Ardehali,A Arneson,C. Scott Baker,Gareth Banks,Katherine Belov
出处
期刊:Nature Aging
日期:2023-08-10
卷期号:3 (9): 1144-1166
被引量:259
标识
DOI:10.1038/s43587-023-00462-6
摘要
Abstract Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy ( r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.
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