胶质瘤
医学
生活质量(医疗保健)
临床试验
疾病
自然史
流行病学
重症监护医学
病理
内科学
癌症研究
护理部
作者
Jason Fangusaro,David Jones,Roger J. Packer,David H. Gutmann,Till Milde,Olaf Witt,Sabine Mueller,Michael J. Fisher,Jordan R. Hansford,Uri Tabori,Darren Hargrave,Pratiti Bandopadhayay
出处
期刊:Neuro-oncology
[Oxford University Press]
日期:2023-11-07
卷期号:26 (1): 25-37
被引量:22
标识
DOI:10.1093/neuonc/noad195
摘要
Abstract The most common childhood central nervous system (CNS) tumor is pediatric low-grade glioma (pLGG), representing 30%–40% of all CNS tumors in children. Although there is high associated morbidity, tumor-related mortality is relatively rare. pLGG is now conceptualized as a chronic disease, underscoring the importance of functional outcomes and quality-of-life measures. A wealth of data has emerged about these tumors, including a better understanding of their natural history and their molecular drivers, paving the way for the use of targeted inhibitors. While these treatments have heralded tremendous promise, challenges remain about how to best optimize their use, and the long-term toxicities associated with these inhibitors remain unknown. The International Pediatric Low-Grade Glioma Coalition (iPLGGc) is a global group of physicians and scientists with expertise in pLGG focused on addressing key pLGG issues. Here, the iPLGGc provides an overview of the current state-of-the-art in pLGG, including epidemiology, histology, molecular landscape, treatment paradigms, survival outcomes, functional outcomes, imaging response, and ongoing challenges. This paper also serves as an introduction to 3 other pLGG manuscripts on (1) pLGG preclinical models, (2) consensus framework for conducting early-phase clinical trials in pLGG, and (3) pLGG resistance, rebound, and recurrence.
科研通智能强力驱动
Strongly Powered by AbleSci AI