并行传输
上皮极性
细胞生物学
细胞内
移液管
生物物理学
化学
生物
膜
生物化学
磁导率
物理化学
作者
Colby F. Lewallen,Athena Chien,Arvydas Maminishkis,Rishabh Hirday,Dominik Reichert,Ruchi Sharma,Qin Wan,Kapil Bharti,Craig R. Forest
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2023-10-30
卷期号:325 (6): C1470-C1484
标识
DOI:10.1152/ajpcell.00200.2023
摘要
This interdisciplinary paper integrates mathematics, biology, and physiology to measure epithelial tissue’s apical, basolateral, and paracellular transport pathways. A key advancement is the inclusion of intracellular voltage recordings using a sharp pipette, enabling precise quantification of relative impedance changes between apical and basolateral membranes. This enhanced electrochemical impedance spectroscopy technique offers insights into epithelial transport dynamics, advancing disease understanding, drug interactions, and cell therapies. Its broad applicability contributes significantly to epithelial physiology research.
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