化学
异喹啉
烯烃
酰胺
催化作用
钯
羰基化
组合化学
有机化学
一氧化碳
作者
Siqi Wang,Shuwei Li,Liangcai Liu,Jun Ying,Xiao-Feng Wu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-01-30
卷期号:25 (5): 821-825
被引量:2
标识
DOI:10.1021/acs.orglett.2c04363
摘要
In this new procedure, amide-containing indolo[2,1-a]isoquinoline scaffolds were prepared by palladium-catalyzed carbonylative cyclization of alkene-tethered indoles with nitroarenes. By using Mo(CO)6 as the CO source and reductant and nitroarenes as the nitrogen source, this reaction produced various amide-containing indolo[2,1-a]isoquinoline derivatives in good yields in general. Furthermore, the late-stage modifications of bioactive molecules using this protocol were demonstrated as well.
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