生物相容性
自愈水凝胶
壳聚糖
再生(生物学)
甲基丙烯酸
材料科学
膜
甲基丙烯酸酯
生物医学工程
组织工程
化学
高分子化学
复合材料
聚合
有机化学
聚合物
医学
生物化学
生物
细胞生物学
作者
Xiaojie Xing,Jingjing Su,Yuan Liu,Honglei Lin,Yinghui Wang,Hui Cheng
标识
DOI:10.1016/j.colsurfb.2022.112760
摘要
Inflammation and trauma destroy the tooth-supporting tissue, leading to the loss of oral function and the difficulty of denture restoration. Guided tissue regeneration (GTR) is a technique based on a barrier membrane designed to restrict soft tissue invasion and maintain the space for bone regeneration. This study examined a new formulation to prepare methacrylated carboxymethyl chitosan (CMCS-MA) hydrogel as a barrier membrane that could be crosslinked under visible-light irradiation. This new CMCS-MA hydrogel showed fast light-curing, good biocompatibility, and could be degraded by lysozyme. Further, the physicochemical property, cytotoxicity and antibacterial activity of the CMCS-MA hydrogels can be adjusted by varying the degree of substitution of methacrylic acid (DS) in a certain range. Thus, the biocompatible and biodegradable CMCS-MA hydrogels may have a promising application in periodontal tissue regeneration with convenience and flexibility.
科研通智能强力驱动
Strongly Powered by AbleSci AI