肠-脑轴
心情
肠道菌群
萧条(经济学)
焦虑
情绪障碍
怀孕
生理学
医学
情感(语言学)
激素
心理学
精神科
内科学
生物
免疫学
宏观经济学
经济
遗传学
沟通
作者
Jia Song,Zhen Bi,Juntao Kan,Guangya Liu,Sheng Zhang,Liang Si,Xianping Zhang,Xue Yang,Jingyun Ma,Junrui Cheng,Yongde Yang,Xiaobo Liu
标识
DOI:10.3389/fcimb.2022.932309
摘要
Perinatal depression is a mood disorder that is reported in women during pregnancy (prenatal) and after childbirth (postnatal). The onset of perinatal depression is associated with changes in reproductive hormones, stress hormones and neurosteroids. These chemical compounds can be modulated by the gut microbiota, which may affect maternal mental health during the perinatal period via the gut-brain-axis. Recent studies suggest that nutritional and dietary interventions (vitamin D, ω-3 fatty acids, iron, and fiber) effectively prevent or mitigate maternal depression and anxiety, but their efficacy is confounded by various factors, including the gut microbiota. Probiotics are efficacious in maintaining microbiota homeostasis, and thus, have the potential to modulate the development of perinatal mood disorders, despite no evidence in human. Therefore, clinical trials are warranted to investigate the role of probiotic supplementation in perinatal depression and behavioral changes. This article reviews the interplay between nutrition, gut microbiota and mood and cognition, and the evidence suggesting that probiotics affect the onset and development of perinatal depression.
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