三氯蔗糖
相对物种丰度
肠道菌群
厚壁菌
生物
荟萃分析
丰度(生态学)
拟杆菌
食品科学
内科学
内分泌学
医学
免疫学
生态学
细菌
遗传学
16S核糖体RNA
作者
Chung‐Yu Chen,Christopher J. Tien,Yue‐Hwa Chen,Daniel Garrido,Aitak Farzi,Herbert Herzog,Hsien‐Yu Fan,Yang‐Ching Chen
标识
DOI:10.1080/87559129.2023.2212045
摘要
Introduction Sucralose is a popular nonnutritive sweetener. The association of sucralose with gut microbiota and its effect on body weight remains unclear; therefore, we examined the effect of sucralose on human and mouse/rat gut microbiota composition.Methods We conducted a systematic review and meta-analysis by including clinical trials on the effect of sucralose on human and mouse/rat gut microbiota composition.Results Of nine studies, two were human trials, and seven were mouse/rat trials. In humans, sucralose intake resulted in significantly higher relative abundance of Bacteroidetes than controls (mean change in relative abundance = 0.24, P < 0.001); however, the converse was observed in mice/rats (mean change in relative abundance = −11.02,P = 0.01). The relative abundance of Actinobacteria significantly increased in humans after sucralose intake (mean change in relative abundance = 0.30, P < 0.01), and the relative abundance of Verrucomicrobia significantly decreased in mice/rats after sucralose intake (mean change in relative abundance = −1.43, P = 0.04).Conclusions Sucralose reduced obesity in humans by reducing the Firmicutes/Bacteroidetes (F/B) ratio and increasing the relative abundance of Actinobacteria. However, sucralose induced obesity in mice/rats by reducing the F/B ratio. More randomized clinical trials and international cooperation in sharing original data are warranted in the future.
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