pH Switchable Nanozyme Platform for Healing Skin Tumor Wound Infected with Drug‐Resistant Bacteria

Nanozymes capable of generating reactive oxygen species have recently emerged as promising treatments for wounds infected with drug-resistant bacteria, possessing a reduced possibility of inducing resistance. However, the therapeutic effect is limited by a shortage of endogenous oxy-substrates and undesirable off-target biotoxicity. Herein, a ferrocenyl coordination polymer (FeCP) nanozyme, featuring pH switchable peroxidase (POD)- and catalase (CAT)-like activity is incorporated with indocyanine green (ICG) and calcium peroxide (CaO2 ) to fabricate an H2 O2 /O2 self-supplying system (FeCP/ICG@CaO2 ) for precise treatment of bacterial infections. At the wound site, CaO2 reacts with water to generate H2 O2 and O2 . Acting as a POD mimic under an acidic bacterial microenvironment, FeCP catalyzes H2 O2 into hydroxyl radicals to prevent infection. However, FeCP switches to CAT-like activity in neutral tissue, decomposing H2 O2 into H2 O and O2 to prevent oxidative damage and facilitate wound healing. Additionally, FeCP/ICG@CaO2 shows photothermal therapy capability, as ICG can emit heat under near-infrared laser irradiation. This heat assists FeCP in fully exerting its enzyme-like activity. Thus, this system achieves an antibacterial efficiency of 99.8% in vitro for drug-resistant bacteria, and effectively overcomes the main limitations of nanozyme-based treatment assays, resulting in satisfactory therapeutic effects in repairing normal and special skin tumor wounds infected with drug-resistant bacteria.