Cribriform morular thyroid carcinoma: a case report with pathological, immunohistochemical, and molecular findings suggesting an origin from follicular cells (or their endodermal precursors)

组织发生 病理 甲状腺癌 旅客8 家族性腺瘤性息肉病 甲状腺球蛋白 生物 甲状腺 筛状 淋巴血管侵犯 免疫组织化学 医学 癌症 内分泌学 结直肠癌 转移 生物化学 遗传学 基因 转录因子
作者
Ana Echegoyen-Silanes,José Javier Pineda-Arribas,María Sánchez‐Ares,Soledad Cameselle-García,Beatriz Sobrino,Clara Ruíz-Ponte,Magalí Piso-Neira,Emma Anda,José Cameselle-Teijeiro
出处
期刊:Virchows Archiv [Springer Nature]
卷期号:482 (3): 615-623 被引量:1
标识
DOI:10.1007/s00428-023-03495-9
摘要

Cribriform morular thyroid carcinoma (CMTC) is a rare malignant thyroid tumor with a peculiar growth pattern secondary to permanent activation of the WNT/β-catenin pathway. CMTC may be associated with familial adenomatous polyposis or sporadic; it shares morphological features with papillary thyroid carcinoma (PTC) and was considered a variant of PTC in the 2017 WHO classification of tumors of endocrine organs. The new 5th edition of the WHO classification of endocrine and neuroendocrine tumors considered CMTC an independent thyroid neoplasm of uncertain histogenesis. A thymic/ultimobranchial pouch-related differentiation in CMTC has been recently postulated. We, however, have used the pathological and immunohistochemical features of this case of CMTC with 2 novel oncogenic somatic variants (c.3428_3429insA, p.(Tyr1143Ter) and c.3565del, p. (Ser1189Hisfs*76) of the APC gene to propose an origin from follicular cells (or their endodermal precursors). As usual in CMTC, the morular component of this tumor was positive for CDX2. Given the fact that WNT/β-catenin signaling, through CDX2, activates large intestine and small intestine gene expression, we postulate that in CMTC, the tumor cells have their terminal differentiation blocked, thus showing a peculiar primitive endodermal (intestinal-like) phenotype negative for sodium-iodide symporter, thyroperoxidase, and thyroglobulin. Establishing the histogenesis of CMTC is very relevant for the development of appropriate therapies of redifferentiation, particularly in patients where the tumor cannot be controlled by surgery.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
十月完成签到,获得积分10
1秒前
1秒前
lrj发布了新的文献求助10
2秒前
丘比特应助海带采纳,获得10
4秒前
5秒前
落寞丹萱发布了新的文献求助10
5秒前
山海之间完成签到,获得积分10
6秒前
TRY发布了新的文献求助10
6秒前
生姜完成签到 ,获得积分10
6秒前
2041完成签到,获得积分10
8秒前
飘逸踏歌完成签到 ,获得积分0
11秒前
充电宝应助落寞丹萱采纳,获得10
11秒前
yanshapo发布了新的文献求助10
12秒前
脑洞疼应助发疯的游子采纳,获得10
14秒前
888发布了新的文献求助20
14秒前
SYLH完成签到,获得积分0
15秒前
lrj完成签到,获得积分20
15秒前
海带完成签到,获得积分10
15秒前
天天快乐应助笨笨的晓夏采纳,获得10
16秒前
高大小懒猪完成签到,获得积分10
17秒前
20秒前
大气的火龙果完成签到 ,获得积分10
20秒前
Charles完成签到,获得积分10
20秒前
薛洁洁的小糖应助888采纳,获得50
20秒前
紫色水晶之恋完成签到 ,获得积分10
22秒前
yanshapo完成签到,获得积分10
25秒前
27秒前
山海发布了新的文献求助10
27秒前
大海的DOI完成签到,获得积分10
28秒前
28秒前
火星上白羊完成签到 ,获得积分10
33秒前
小蘑菇应助科研通管家采纳,获得10
33秒前
研友_VZG7GZ应助科研通管家采纳,获得10
33秒前
梁三柏应助科研通管家采纳,获得20
33秒前
田様应助科研通管家采纳,获得10
33秒前
33秒前
桐桐应助科研通管家采纳,获得10
33秒前
汉堡包应助科研通管家采纳,获得10
33秒前
赤木完成签到 ,获得积分10
34秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572296
求助须知:如何正确求助?哪些是违规求助? 3142501
关于积分的说明 9448015
捐赠科研通 2843973
什么是DOI,文献DOI怎么找? 1563103
邀请新用户注册赠送积分活动 731630
科研通“疑难数据库(出版商)”最低求助积分说明 718640