真菌
化学
植物
球毛壳菌
毛壳
聚酮
生物
有机化学
食品科学
生物合成
酶
青霉属
作者
Yinyin Wang,Yin‐Bo Pan,Ze‐Yi Wan,Jun‐Jiang Li,Jie Bao,Jun‐Sheng Zhang,Hua Zhang
标识
DOI:10.1002/cbdv.202400002
摘要
Seven new polyketides including three chromone derivatives (1-3) and four linear ones incorporating a tetrahydrofuran ring (4-7), along with three known compounds (8-10), were obtained from the fermentation of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated from the leaves of Vaccinium bracteatum. The structures of these fungal metabolites have been elucidated by spectroscopic means including MS, NMR and electronic circular dichroism. A preliminary anti-inflammatory screening with the lipopolysaccharide (LPS) induced RAW264.7 cell model revealed moderate NO production inhibitory activity for compounds 1 and 4. In addition, the expression of three LPS-induced inflammatory factors IL-6, iNOS and COX-2 was also blocked by 1 and 4.
科研通智能强力驱动
Strongly Powered by AbleSci AI