益生元
安慰剂
微生物群
肠道菌群
认知
随机对照试验
人口
肠道微生物群
肠-脑轴
合成代谢
生物信息学
医学
物理医学与康复
物理疗法
生理学
生物
内科学
免疫学
食品科学
精神科
病理
替代医学
环境卫生
作者
Mary Ní Lochlainn,Ruth C. E. Bowyer,Marie-Hélène Pinard-van Der Laan,María Paz García,Samuel Wadge,Andrei-Florin Baleanu,Ayrun Nessa,Alyce Sheedy,Gulsah Akdag,Deborah Hart,Giulia Raffaele,Paul T. Seed,Caroline Murphy,Stephen D. R. Harridge,Ailsa Welch,Carolyn Greig,Kevin Whelan,Claire J. Steves
标识
DOI:10.1038/s41467-024-46116-y
摘要
Abstract Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive either placebo or prebiotic daily for 12 weeks. Resistance exercise and branched chain amino acid (BCAA) supplementation is prescribed to all participants. Outcomes are physical function and cognition. The trial is carried out remotely using video visits, online questionnaires and cognitive testing, and posting of equipment and biological samples. The prebiotic supplement is well tolerated and results in a changed gut microbiome [e.g., increased relative Bifidobacterium abundance]. There is no significant difference between prebiotic and placebo for the primary outcome of chair rise time (β = 0.579; 95% CI −1.080-2.239 p = 0.494). The prebiotic improves cognition (factor score versus placebo (β = −0.482; 95% CI,−0.813, −0.141; p = 0.014)). Our results demonstrate that cheap and readily available gut microbiome interventions may improve cognition in our ageing population. We illustrate the feasibility of remotely delivered trials for older people, which could reduce under-representation of older people in clinical trials. ClinicalTrials.gov registration: NCT04309292.
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