医学
吲哚青绿
淋巴结切除术
解剖(医学)
淋巴结
腹腔镜检查
新辅助治疗
胃切除术
癌症
放射科
内科学
外科
乳腺癌
作者
Ze-Ning Huang,Yi-Hui Tang,Qing Zhong,Ping Li,Jian‐Wei Xie,Jia‐Bin Wang,Jian‐Xian Lin,Jun Lu,Long‐Long Cao,Mi Lin,Ru‐Hong Tu,Chao‐Hui Zheng,Qi‐Yue Chen,Chang‐Ming Huang
出处
期刊:Annals of Surgery
[Ovid Technologies (Wolters Kluwer)]
日期:2024-02-20
被引量:2
标识
DOI:10.1097/sla.0000000000006242
摘要
Objective: To assess the effectiveness of indocyanine green (ICG)-guided lymph node (LN) dissection during laparoscopic radical gastrectomy after neoadjuvant chemotherapy (NAC) in patients with LAGC. Summary Background Data: Studies on ICG imaging use in patients with LAGC on NAC are rare. Methods: Patients with gastric adenocarcinoma (clinical T2-4NanyM0) who received NAC were randomly assigned to receive ICG-guided laparoscopic radical gastrectomy or laparoscopic radical gastrectomy alone. Here, we reported the secondary endpoints including the quality of lymphadenectomy (total retrieved LNs and LN noncompliance) and surgical outcomes. Results: Overall, 240 patients were randomized. Of whom, 236 patients were included in the primary analysis (118 in the ICG group and 118 in the non-ICG group). In the ICG group, the mean number of LNs retrieved was significantly higher than in the non-ICG group within the D2 dissection (48.2 vs. 38.3, P <0.001). The ICG fluorescence guidance significantly decreased the LN non-compliance rates (33.9% vs. 55.1%, P =0.001). In 165 patients without baseline measurable LNs, ICG significantly increased the number of retrieved LNs and decreased the LN non-compliance rate ( P <0.05). For 71 patients with baseline measurable LNs, the quality of lymphadenectomy significantly improved in those who had a complete response ( P <0.05) but not in those who did not ( P >0.05). Surgical outcomes were comparable between the groups ( P >0.05). Conclusions: ICG can effectively improve the quality of lymphadenectomy in patients with LAGC who underwent laparoscopic radical gastrectomy after NAC.
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