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Psoriasis dermatitis, a common phenotype of early forms of both psoriasis and atopic dermatitis in children: A prospective multicenter study

医学 银屑病 特应性皮炎 流行病学 皮肤病科 前瞻性队列研究 队列 人口 疾病 儿科 队列研究 家族史 内科学 环境卫生
作者
Alexandre Docampo‐Simón,I. Belinchón,M. Pujol,L. Berbegal,Julia Miralles,Ana Lucas,Esther Quecedo,Amparo Fuertes,Almudena Mateu‐Puchades,Isabel Betlloch
出处
期刊:International Journal of Dermatology [Wiley]
被引量:2
标识
DOI:10.1111/ijd.17100
摘要

Abstract Background Psoriasis (Ps) and atopic dermatitis (AD) are chronic systemic immune‐mediated diseases that can coexist in an overlapping condition called psoriasis dermatitis (PD). PD patients have intermediate lesions with characteristics of both Ps and AD. PD is very rare in adults but much more frequent in children. Little is known, however, about the course of PD in the pediatric population. The aim of this study was to evaluate the percentage of PD cases in children that evolved to a definite form of Ps or AD and to identify any clinical or epidemiological variables that could predict the course of the disease. Methods We performed a prospective multicenter cohort study of children diagnosed with PD between January 2018 and December 2020. We collected participants' clinical and epidemiological characteristics, and pediatric dermatologists determined the percentage of participants who developed Ps or AD. Results The study included 24 children with PD, with a median age of 7.0 years. After a median follow‐up period of 31 months, 83.3% of cases had evolved to a definite form of Ps or AD (44.4% to Ps and 38.9% to AD). Younger age and family history of Ps were associated with progression to AD. Participants who progressed to AD or Ps had a longer follow‐up than those with an unchanged PD diagnosis. Conclusions Given sufficient time, a large percentage of PD cases in children will evolve into Ps or AD. Long‐term clinical follow‐up is necessary for a correct diagnosis.
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