体内
体外
免疫疗法
免疫学
淋巴因子激活杀伤细胞
生物
医学
癌症研究
化学
免疫系统
T细胞
白细胞介素21
生物技术
生物化学
作者
Kawaljit Kaur,Anahid Jewett
标识
DOI:10.1615/critrevimmunol.2024052389
摘要
Despite advancements in the field of cancer therapeutics, the five-year survival rate remains low in oral cancer patients. Therefore, the effective therapeutics are needed against oral cancer. Also, several studies including ours, have shown severely suppressed function and number of NK cells in oral cancer patients. In this review, we discuss the approach to inhibit the tumor growth and metastasis by direct killing or NK cell-mediated tumor differentiation. This review also provides an overview on supercharging NK cells using osteoclasts and probiotic bacteria, and their efficacy as cancer immunotherapeutic in humanized-BLT mice.
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