观察研究
孟德尔随机化
骨质疏松症
混淆
钙化
医学
内科学
心脏病学
生物
生物化学
遗传变异
基因型
基因
作者
Xi Nie,Qiong Zhang,Yixuan Wang,Zhaoliang Liu,Dongfang Xie,Qingxu Song,Chen Yang,Tiecheng Yu,Yang Sun
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2024-01-12
卷期号:34 (2)
被引量:1
标识
DOI:10.1093/cercor/bhad528
摘要
Abstract Observational studies have reported that osteoporosis is associated with cortical changes in the brain. However, the inherent limitations of observational studies pose challenges in eliminating confounding factors and establishing causal relationships. And previous observational studies have not reported changes in specific brain regions. By employing Mendelian randomization, we have been able to infer a causal relationship between osteoporosis and a reduction in the surficial area (SA) of the brain cortical. This effect is partially mediated by vascular calcification. We found that osteoporosis significantly decreased the SA of global brain cortical (β = −1587.62 mm2, 95%CI: −2645.94 mm2 to −529.32 mm2, P = 0.003) as well as the paracentral gyrus without global weighted (β = − 19.42 mm2, 95%CI: −28.90 mm2 to −9.95 mm2, P = 5.85 × 10−5). Furthermore, we estimated that 42.25% and 47.21% of the aforementioned effects are mediated through vascular calcification, respectively. Osteoporosis leads to a reduction in the SA of the brain cortical, suggesting the presence of the bone-brain axis. Vascular calcification plays a role in mediating this process to a certain extent. These findings establish a theoretical foundation for further investigations into the intricate interplay between bone, blood vessels, and the brain.
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