α-突触核蛋白
细胞外小泡
细胞外
小泡
帕金森病
病理
细胞生物学
胞外囊泡
化学
生物
生物化学
微泡
医学
小RNA
疾病
膜
基因
作者
Yuta Ishiguro,Taiji Tsunemi,Tomoyo Shimada,Asako Yoroisaka,Shinichi Ueno,Haruka Takeshige‐Amano,Taku Hatano,Yuichi Inoue,Sachio Saiki,Nobutaka Hattori
标识
DOI:10.1016/j.bbrc.2024.149620
摘要
Parkinson's disease (PD) is characterized by the pathological deposition of a-synuclein (a-syn) inclusions, known as Lewy bodies/neurites. Emerging evidence suggests that extracellular vesicles (EVs) play a role in facilitating the spreading of Lewy pathology between the peripheral nervous system and the central nervous system. We analyzed serum EVs obtained from patients with PD (n = 142), multiple system atrophy (MSA) (n = 18), progressive supranuclear palsy (PSP) (n = 28), rapid eye movement sleep behavior disorder (n = 31), and controls (n = 105). While we observed a significant reduction in the number of EVs in PD compared to controls (p = 0.006), we also noted a substantial increase in filamentous α-synuclein within EVs in PD compared to controls (p < 0.0001), MSA (0.012), and PSP (p = 0.03). Further analysis unveiled the role of EVs in facilitating the transmission of filamentous α-synuclein between neurons and from peripheral blood to the CNS. These findings highlight the potential utility of serum α-synuclein filaments within EVs as diagnostic markers for synucleinopathies and underscore the significance of EVs in promoting the dissemination of filamentous α-synuclein throughout the entire body.
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