细胞周期蛋白依赖激酶
细胞周期
细胞生物学
限制点
激酶
有丝分裂
生物
细胞生长
细胞周期检查点
细胞周期蛋白
Polo样激酶
细胞周期蛋白依赖激酶1
细胞周期蛋白
癌症研究
细胞
生物化学
出处
期刊:Advances in protein chemistry and structural biology
日期:2023-01-01
卷期号:: 313-342
被引量:3
标识
DOI:10.1016/bs.apcsb.2023.02.003
摘要
Cancer has been linked to the uncontrolled proliferation of cells and the overexpression of cell-cycle genes. The cell cycle machinery plays a crucial role in the regulation of the apoptosis to mitosis to growth phase progression. The mechanisms of the cell cycle also play an important role in preventing DNA damage. There are multiple members of the protein kinase family that are involved in the activities of the cell cycle. Essential cyclins effectively regulate cyclin-dependent kinases (CDKs), which are themselves adversely regulated by naturally occurring CDK inhibitors. Despite the fact that various compounds can effectively block the cell cycle kinases and being investigated for their potential to fight cancer. This chapter explains the detail of cell cycle and checkpoint regulators, that are crucial to the malignant cellular process. The known CDKs inhibitors and their mechanism of action in various cancers have also been addressed as a step toward the development of a possibly novel technique for the design of new drugs against cell cycle kinase proteins.
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