巨噬细胞极化
细胞生物学
免疫疗法
受体
巨噬细胞
化学
生物
癌症研究
免疫学
免疫系统
遗传学
体外
作者
Si Qin,Lu Yang,Simin Liu,Hui Liu,Ruifang Bu,Na Cui
出处
期刊:Immunobiology
[Elsevier]
日期:2024-12-13
卷期号:230 (1): 152863-152863
标识
DOI:10.1016/j.imbio.2024.152863
摘要
A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor-infiltrating macrophages. P2X7 receptor has been previously documented as expressed within these macrophages and its correlation with M2 polarization is evident. This investigation scrutinizes whether silencing of P2X7 receptor within macrophages could lead to augmented anti-tumor potency of CAR-T.
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